drugset / Trial / NCT04144023

A Vaccine (H2NVAC) Before Surgery for the Treatment of HER2-Expressing Ductal Carcinoma In Situ

NCT04144023

Phase 1 Recruiting 43 enrolled Mayo Clinic
NaSingle-groupOpen-labelTreatment

Summary

This phase Ib trial studies the side effects and best dose of a vaccine called H2NVAC before surgery in treating patients with HER2 expressing ductal carcinoma in situ. H2NVAC is a vaccine designed to stimulate specialized white blood cells in hopes of increasing immune response and protecting against breast cancer.

Timeline

Start
2019-06-27
Primary completion
2027-12-31
Completion
2027-12-31

Drugs

EvaluationDrugModalityDoseRoute
Subject H2NVAC Vaccine Intrathecal
Background sargramostim Protein / enzyme biologic Intrathecal