drugset / Trial / NCT04154488

A Study of Mavorixafor in Participants With Congenital Neutropenia and Chronic Idiopathic Neutropenia Disorders

NCT04154488

Phase 1/2 Completed 32 enrolled X4 Pharmaceuticals
NaSingle-groupOpen-labelTreatment

Summary

This is a 2-part study of mavorixafor in participants diagnosed with chronic neutropenia. The main goal of Part 1 (Phase 1b) is to help researchers learn more about how the investigational medicine, mavorixafor, impacts people living with chronic neutropenia (including congenital, idiopathic, and cyclic). In Part 2 (Phase 2), the safety and tolerability of chronic dosing of mavorixafor will be evaluated in a larger participant population and the impact of 6-month chronic dosing of mavorixafor on participant neutropenia.

Timeline

Start
2021-10-16
Primary completion
2024-08-27
Completion
2024-08-27

Drugs

EvaluationDrugModalityDoseRoute
Subject Mavorixafor Small molecule 200 mg Oral
Subject Mavorixafor Small molecule 400 mg Oral

Indications