Ketamine-Induced Brain Changes and Their Modulation by Lamotrigine

Completed 75 enrolled Charite University, Berlin, Germany Boehringer Ingelheim · collab

RandomizedParallel-groupDouble-blindBasic science

Summary

This study is firstly designed to investigate acute and delayed effects of a single dose of ketamine on functional brain changes during emotional and cognitive challenges and at rest. Secondly, it aims to investigate whether functional brain changes after ketamine require increased glutamatergic signaling and will accordingly be modulated after pretreatment with lamotrigine.

Timeline

Start: 2020-03-10
Primary completion: 2020-12-10
Completion: 2020-12-10

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.31 mg/kg	Intravenous
Subject	Lamotrigine	Small molecule	300 mg	Oral

Indications

No indication recorded.