A Clinical Trial of Fluvoxamine for Melancholia

Summary

This study aims at investigating the special effectiveness of antidepressant effect of Fluvoxamine for endogenous depression. The investigators also aim to assess the effect of Fluvoxamine on the multimodal magnetic resonance imaging(MRI), blood cytokines, feces bacteria flora and neuropsychological performance in depression patients with melancholic features. The investigators further aim to identify the predictors of Fluvoxamine's antidepressant effeect using the above techniques.

Timeline

Start

2019-08-01

Primary completion

2022-06-30

Completion

2022-09-30

Publications

• Li X, Yan D, Liao M, Zhang L, Li Z, Liu B, Chen Y, Zhang Y, Liu J, Li L. Effect of fluvoxamine on plasma interleukin-6 in patients with major depressive disorder: a prospective follow-up study. Front Psychiatry. 2023 May 25;14:1163754. doi: 10.3389/fpsyt.2023.1163754. eCollection 2023.

Drugs

Indications