Live Attenuated Influenza Vaccine as a Nasal Model for Influenza Infection

Summary

The purpose of this study is to develop a nasal model for influenza infection using the live attenuated influenza vaccine (LAIV). The investigators will administer LAIV to healthy adult volunteers in order to simulate influenza infection, and obtain nasal specimens to measure influenza virus and inflammatory/immune responses. In a subset of participants, cystic fibrosis transmembrane conductance regulator (CFTR) function will also be evaluated via measurement of nasal potential difference (NPD)

Timeline

Start

2020-09-01

Primary completion

2026-01-22

Completion

2026-01-22

Publications

• Earnhardt EY, Tipper JL, Hanafy MA, Lazrak A, Lopez A, Perritt SE, LaFon DC, Mobley JA, Solomon GM, Harrod KS. Endoplasmic Reticulum Stress Disrupts the Airway Epithelium and Reduces Host Defense during Influenza A Virus Infection. Am J Respir Cell Mol Biol. 2026 Jan 1;74(1):40-51. doi: 10.1165/rcmb.2025-0141OC.

Drugs

Indications