Topography Staging and Dual Phase Image Quantification of Tau PET in Cognitive Impairment Subjects

Summary

A second-generation tau PET image tracer 18F-PM-PBB3 (APN-1607 or MNI-958) has been developed by National Institute of Radiological Sciences. The new tracer solved the off-target binding issue. This study will evaluate new quantitative methods with PMPBB3, by utilized dual phase scanning protocol to extract blood flow and Tau protein binding information, to evaluate appropriate reference brain regions, to improve the normalization efficiency of brain imaging, and to establish a brain template image analysis platform.

Timeline

Start

2019-04-01

Primary completion

2023-03-31

Completion

2023-09-30

Drugs

Indications