Effect of Ketamine on Laboratory-induced Stress in Healthy Subjects

Phase 2 Completed 24 enrolled Icahn School of Medicine at Mount Sinai

RandomizedParallel-groupQuadruple-blindPrevention

Summary

The objective of this study is to examine the effect of a single IV dose of ketamine (0.5 mg/kg) on laboratory-induced stress in healthy participants.

Timeline

Start: 2019-08-08
Primary completion: 2021-03-18
Completion: 2021-03-18

Publications

Background O'Halloran PD, Murphy GC, Webster KE. Reliability of the bipolar form of the profile of mood states using an alternative test protocol. Psychol Rep. 2004 Oct;95(2):459-63. doi: 10.2466/pr0.95.2.459-463.
Background Beck AT, Epstein N, Brown G, Steer RA. An inventory for measuring clinical anxiety: psychometric properties. J Consult Clin Psychol. 1988 Dec;56(6):893-7. doi: 10.1037//0022-006x.56.6.893. No abstract available.
Background Crawford JR, Henry JD. The positive and negative affect schedule (PANAS): construct validity, measurement properties and normative data in a large non-clinical sample. Br J Clin Psychol. 2004 Sep;43(Pt 3):245-65. doi: 10.1348/0144665031752934.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Ketamine	Small molecule	0.5 mg/kg	Intravenous
Comparator	Midazolam	Small molecule	0.045 mg/kg	Intravenous

Indications

No indication recorded.