Effect of Injectable Platelet-Rich Fibrin (i-PRF) in Initial Treatment of Chronic Periodontitis
Summary
Current treatments of periodontitis have limited efficacy since they fail to suppress microorganisms satisfactorily over time. The aim of present study was to investigate whether there are differences between initial treatment of chronic periodontitis (SRP) and SRP in conjunction with injectable platelet-rich fibrin (i-PRF) application.
Timeline
- Start
- 2019-10-02
- Primary completion
- 2020-06-29
- Completion
- 2020-07-09
Outcome
Mixed primary results
registry MEAN SRP + Injectable Platelet-Rich Fibrin: 2.398 (Standard Deviation 0.792) mm NCT04178590 ↗
registry MEAN SRP + Placebo: 2.876 (Standard Deviation 0.804) mm NCT04178590 ↗
registry analysis (superiority test); SRP + Injectable Platelet-Rich Fibrin vs SRP + Placebo; p = 0.000 NCT04178590 ↗
registry MEAN SRP + Injectable Platelet-Rich Fibrin: 3.735 (Standard Deviation 0.863) mm NCT04178590 ↗
registry MEAN SRP + Placebo: 3.696 (Standard Deviation 0.851) mm NCT04178590 ↗
registry analysis (superiority test); SRP + Injectable Platelet-Rich Fibrin vs SRP + Placebo; p = 0.429 NCT04178590 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Injectable Platelet-Rich Fibrin | Unknown | — | — |