drugset / Trial / NCT04180215
A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other Cancers
Non-randomizedSequentialOpen-labelTreatment
Summary
This is a First in Human (FIH) Phase I/II, multinational, multicenter, open-label study of HB-201 single vector therapy and HB-201 \& HB-202 two-vector therapy in patients with HPV 16+ confirmed cancers comprising two parts: Phase I Dose Escalation and Phase II Dose Expansion.
Timeline
- Start
- 2019-12-11
- Primary completion
- 2025-01-09
- Completion
- 2025-01-09
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | HB-201 | Vaccine | — | Intravenous |
| Subject | HB-202 | Vaccine | — | Intravenous |
| Subject | Zr-Df-IAB22M2C | Diagnostic / imaging agent | — | — |
| Background | Pembrolizumab | Monoclonal antibody | — | — |