Azithromycin Reduction to Reach Elimination of Trachoma

Phase 4 Completed 3931 enrolled University of California, San Francisco National Eye Institute (NEI) · collab Programme National de Santé Oculaire (PNSO) · collab

RandomizedParallel-groupDouble-blindTreatment

Summary

The investigators propose a randomized controlled trial of discontinuation versus continuation of annual mass azithromycin distribution in hypoendemic communities of Maradi, Niger. The investigators will randomize communities with up to 20% Trachomatous Inflammation - Follicular (TF) prevalence following at least 5 years of mass azithromycin distribution to discontinuation or continuation of 3 additional years of annual mass azithromycin distribution.

Timeline

Start: 2021-05-29
Primary completion: 2024-12-18
Completion: 2024-12-18

Publications

Amza A, Kadri B, Nassirou B, Arzika AM, Austin A, Nyatigo F, Lebas E, Arnold BF, Lietman TM, Oldenburg CE. Azithromycin Reduction to Reach Elimination of Trachoma (ARRET): study protocol for a cluster randomized trial of stopping mass azithromycin distribution for trachoma. BMC Ophthalmol. 2021 Jan 6;21(1):15. doi: 10.1186/s12886-020-01776-4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Azithromycin	Small molecule	20 mg/kg	Oral
Comparator	Azithromycin	Small molecule	1 g	Oral

Azithromycin Reduction to Reach Elimination of Trachoma

Summary

Timeline

Publications

Drugs

Indications