drugset / Trial / NCT04187456
A Study in Healthy Male Subjects to Understand How Savolitinib When Taken With Midazolam Behaves Inside the Body
Non-randomizedSequentialOpen-labelTreatment
Summary
This study will be an open label, 2 period, fixed sequence study in healthy male subjects, performed at a single study center in the Unites States of America. The purpose of this study is to evaluate the effect of savolitinib on the PK of midazolam, a known cytochrome P450 (CYP) 3A substrate.
Timeline
- Start
- 2019-12-27
- Primary completion
- 2020-03-06
- Completion
- 2020-03-06
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Midazolam | Small molecule | 1 mg | — |
| Subject | Savolitinib | Small molecule | 600 mg | — |