drugset / Trial / NCT04187456

A Study in Healthy Male Subjects to Understand How Savolitinib When Taken With Midazolam Behaves Inside the Body

NCT04187456

Phase 1 Completed 14 enrolled AstraZeneca Parexel · collab
Non-randomizedSequentialOpen-labelTreatment

Summary

This study will be an open label, 2 period, fixed sequence study in healthy male subjects, performed at a single study center in the Unites States of America. The purpose of this study is to evaluate the effect of savolitinib on the PK of midazolam, a known cytochrome P450 (CYP) 3A substrate.

Timeline

Start
2019-12-27
Primary completion
2020-03-06
Completion
2020-03-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Midazolam Small molecule 1 mg
Subject Savolitinib Small molecule 600 mg

Indications