Safety and Pharmacokinetics/Pharmacodynamics of HSK3486 in Healthy Elderly Subjects

NCT04197661 ↗

Phase 1 Completed 32 enrolled Sichuan Haisco Pharmaceutical Group Co., Ltd The First Hospital of Jilin University · collab

RandomizedParallel-groupOpen-labelOther

Summary

It is a single-center, open-label, dose-finding, Phase I clinical study evaluating the pharmacokinetics, pharmacodynamics, and safety characteristics of HSK3486 in healthy elderly subjects.

Timeline

Start: 2019-12-25
Primary completion: 2020-01-22
Completion: 2020-05-22

Publications

Results Qin L, Ren L, Wan S, Liu G, Luo X, Liu Z, Li F, Yu Y, Liu J, Wei Y. Design, Synthesis, and Evaluation of Novel 2,6-Disubstituted Phenol Derivatives as General Anesthetics. J Med Chem. 2017 May 11;60(9):3606-3617. doi: 10.1021/acs.jmedchem.7b00254. Epub 2017 Apr 28.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Cipepofol	Small molecule	0.2 mg/kg	Intravenous
Comparator	Cipepofol	Small molecule	0.3 mg/kg	Intravenous
Comparator	Cipepofol	Small molecule	0.4 mg/kg	Intravenous

Indications

No indication recorded.