An Efficacy and Safety Study of Ravulizumab in Adult Participants With NMOSD

Summary

The primary purpose of this study is to evaluate the efficacy and safety of ravulizumab for the treatment of adult participants with NMOSD.

Timeline

Start

2019-12-09

Primary completion

2022-03-15

Completion

2024-10-31

Publications

• Pittock SJ, Barnett MH, Bennett JL, Berthele A, de Seze J, Levy M, Nakashima I, Oreja-Guevara C, Palace J, Paul F, Pozzilli C, Pathak R, Allen K, Parks B, Kim HJ. Long-Term Ravulizumab Efficacy and Safety in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder: Final CHAMPION-NMOSD Results. Neurol Neuroimmunol Neuroinflamm. 2026 Sep;13(5):e200609. doi: 10.1212/NXI.0000000000200609. Epub 2026 Jul 13.
• Bennett JL, Bhattacharyya S, Zabeti A, Levy M, de Seze J, Taney MJ, Parks B, Allen K, Akpoji U, Pittock SJ. Safety and efficacy of ravulizumab in patients with NMOSD previously treated with rituximab: A post hoc analysis of the CHAMPION-NMOSD trial. Mult Scler. 2026 Apr;32(4):396-408. doi: 10.1177/13524585261425076. Epub 2026 Mar 4.
• Ortiz S, Pittock SJ, Berthele A, Levy M, Nakashima I, Oreja-Guevara C, Allen K, Mashhoon Y, Parks B, Kim HJ. Immediate and sustained terminal complement inhibition with ravulizumab in patients with anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder. Front Neurol. 2024 Jan 31;15:1332890. doi: 10.3389/fneur.2024.1332890. eCollection 2024.

Drugs

Indications