EMG for Uterotonic Efficiency Estimation

NCT04201665 ↗

Completed 60 enrolled University Medical Centre Ljubljana

RandomizedParallel-groupOpen-labelTreatment

Summary

Studies found conflicting results on efficacy of uterotonic agents used to prevent and treat uterine atony, the most common cause of postpartum hemorrhage. Uterine EMG can be used to objectively assess myometrial contractility and, consequently, efficacy of different uterotonics. The investigators are planning a single-center, randomized, open-label trial to compare uterine EMG parameters in women receiving oxytocin vs. those receiving carbetocin after cesarean delivery.

Timeline

Start: 2020-09-13
Primary completion: 2022-01-31
Completion: 2022-01-31

Publications

Paljk Likar I, Becic E, Pezdirc N, Gersak K, Lucovnik M, Trojner Bregar A. Comparison of Oxytocin vs. Carbetocin Uterotonic Activity after Caesarean Delivery Assessed by Electrohysterography: A Randomised Trial. Sensors (Basel). 2022 Nov 21;22(22):8994. doi: 10.3390/s22228994.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Carbetocin	Peptide	100 ug	Intramuscular
Comparator	Oxytocin	Peptide	5 iu	Intravenous
Comparator	Oxytocin	Peptide	10 iu	Intravenous

Indications

No indication recorded.