Oral Dextrose Formula in Performance of Soccer Athlete
Summary
I. Title of Proposed Research Project Dextrose 10% Drink Increase Blood Sugar and Sprint Velocity Compared to Sodium Dextrose in Soccer Players II. Specific Aims This study aims to evaluate the ergogenic effect in terms of blood sugar, VO2 max and sprint speed of dextrose 10% compared with sodium dextrose 10% in young male soccer players. III. Background Sports drinks are designed to provide CHO, electrolytes, and fluids to the body, which are absorbed very fast from the small intestine. In other words, the period from ingestion until the CHO, electrolytes, and fluids reach the muscles, brain and so on, should be very short. This is the most important advantage of using sports drinks (Simulescu, Ilia, Macarie, \& Merghes, 2019). Commercial sports drinks generally contain both of CHO and sodium; To the best of the investigator's knowledge, there is no trial in which compare the differential effect of solely dextrose supplementation versus sodium dextrose in soccer players in terms of BG concentration, VO2 max and sprint speed, which may give a new paradigm for the available ergogenic sports drink.
Timeline
- Start
- 2019-03-25
- Primary completion
- 2019-05-28
- Completion
- 2019-06-30
Publications
- Background Achten J, Halson SL, Moseley L, Rayson MP, Casey A, Jeukendrup AE. Higher dietary carbohydrate content during intensified running training results in better maintenance of performance and mood state. J Appl Physiol (1985). 2004 Apr;96(4):1331-40. doi: 10.1152/japplphysiol.00973.2003. Epub 2003 Dec 5.
- Background Afshar N, Safaei S, Nickerson DP, Hunter PJ, Suresh V. Computational Modeling of Glucose Uptake in the Enterocyte. Front Physiol. 2019 Apr 12;10:380. doi: 10.3389/fphys.2019.00380. eCollection 2019.
- Background Amann M. Pulmonary system limitations to endurance exercise performance in humans. Exp Physiol. 2012 Mar;97(3):311-8. doi: 10.1113/expphysiol.2011.058800. Epub 2011 Nov 28.
- Background Baker LB, Rollo I, Stein KW, Jeukendrup AE. Acute Effects of Carbohydrate Supplementation on Intermittent Sports Performance. Nutrients. 2015 Jul 14;7(7):5733-63. doi: 10.3390/nu7075249.
- Background Bangsbo J, Iaia FM, Krustrup P. Metabolic response and fatigue in soccer. Int J Sports Physiol Perform. 2007 Jun;2(2):111-27. doi: 10.1123/ijspp.2.2.111.
- Background Boyd CA, Parsons DS. Movements of monosaccharides between blood and tissues of vascularly perfused small intestine. J Physiol. 1979 Feb;287:371-91. doi: 10.1113/jphysiol.1979.sp012665.
- Background Burke LM, Meyer NL, Pearce J. National Nutritional Programs for the 2012 London Olympic Games: a systematic approach by three different countries. Nestle Nutr Inst Workshop Ser. 2013;76:103-20. doi: 10.1159/000350263. Epub 2013 Jul 25.
- Background Dobbins RL, Greenway FL, Chen L, Liu Y, Breed SL, Andrews SM, Wald JA, Walker A, Smith CD. Selective sodium-dependent glucose transporter 1 inhibitors block glucose absorption and impair glucose-dependent insulinotropic peptide release. Am J Physiol Gastrointest Liver Physiol. 2015 Jun 1;308(11):G946-54. doi: 10.1152/ajpgi.00286.2014. Epub 2015 Mar 12.
- Background Esposito BP, Breuer W, Sirankapracha P, Pootrakul P, Hershko C, Cabantchik ZI. Labile plasma iron in iron overload: redox activity and susceptibility to chelation. Blood. 2003 Oct 1;102(7):2670-7. doi: 10.1182/blood-2003-03-0807. Epub 2003 Jun 12.
- Background F Alghannam, A. (2013). Physiology of Soccer: The Role of Nutrition in Performance. Journal of Novel Physiotherapies. https://doi.org/10.4172/2165-7025.s3-003
- Background Gabbett TJ, Mulvey MJ. Time-motion analysis of small-sided training games and competition in elite women soccer players. J Strength Cond Res. 2008 Mar;22(2):543-52. doi: 10.1519/JSC.0b013e3181635597.
- Background Godek SF, Peduzzi C, Burkholder R, Condon S, Dorshimer G, Bartolozzi AR. Sweat rates, sweat sodium concentrations, and sodium losses in 3 groups of professional football players. J Athl Train. 2010 Jul-Aug;45(4):364-71. doi: 10.4085/1062-6050-45.4.364.
- Background Hills SP, Russell M. Carbohydrates for Soccer: A Focus on Skilled Actions and Half-Time Practices. Nutrients. 2017 Dec 25;10(1):22. doi: 10.3390/nu10010022.
- Background Jentjens RL, Achten J, Jeukendrup AE. High oxidation rates from combined carbohydrates ingested during exercise. Med Sci Sports Exerc. 2004 Sep;36(9):1551-8. doi: 10.1249/01.mss.0000139796.07843.1d.
- Background Jeukendrup A. A step towards personalized sports nutrition: carbohydrate intake during exercise. Sports Med. 2014 May;44 Suppl 1(Suppl 1):S25-33. doi: 10.1007/s40279-014-0148-z.
- Background Jeukendrup AE. Training the Gut for Athletes. Sports Med. 2017 Mar;47(Suppl 1):101-110. doi: 10.1007/s40279-017-0690-6.
- Background Kellett GL. The facilitated component of intestinal glucose absorption. J Physiol. 2001 Mar 15;531(Pt 3):585-95. doi: 10.1111/j.1469-7793.2001.0585h.x.
- Background Kellett GL, Brot-Laroche E. Apical GLUT2: a major pathway of intestinal sugar absorption. Diabetes. 2005 Oct;54(10):3056-62. doi: 10.2337/diabetes.54.10.3056.
- Background Kellett GL, Brot-Laroche E, Mace OJ, Leturque A. Sugar absorption in the intestine: the role of GLUT2. Annu Rev Nutr. 2008;28:35-54. doi: 10.1146/annurev.nutr.28.061807.155518.
- Background Kimmich GA, Randles J. Sodium-sugar coupling stoichiometry in chick intestinal cells. Am J Physiol. 1984 Jul;247(1 Pt 1):C74-82. doi: 10.1152/ajpcell.1984.247.1.C74.
- Background Kingsley M, Penas-Ruiz C, Terry C, Russell M. Effects of carbohydrate-hydration strategies on glucose metabolism, sprint performance and hydration during a soccer match simulation in recreational players. J Sci Med Sport. 2014 Mar;17(2):239-43. doi: 10.1016/j.jsams.2013.04.010. Epub 2013 May 20.
- Background Mace OJ, Affleck J, Patel N, Kellett GL. Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol. 2007 Jul 1;582(Pt 1):379-92. doi: 10.1113/jphysiol.2007.130906. Epub 2007 May 10.
- Background Mace OJ, Morgan EL, Affleck JA, Lister N, Kellett GL. Calcium absorption by Cav1.3 induces terminal web myosin II phosphorylation and apical GLUT2 insertion in rat intestine. J Physiol. 2007 Apr 15;580(Pt. 2):605-16. doi: 10.1113/jphysiol.2006.124784. Epub 2007 Feb 1.
- Background MacLeod RJ, Hamilton JR. Volume regulation initiated by Na(+)-nutrient cotransport in isolated mammalian villus enterocytes. Am J Physiol. 1991 Jan;260(1 Pt 1):G26-33. doi: 10.1152/ajpgi.1991.260.1.G26.
- Background Naftalin RJ. Does apical membrane GLUT2 have a role in intestinal glucose uptake? F1000Res. 2014 Dec 12;3:304. doi: 10.12688/f1000research.5934.1. eCollection 2014.
- Background Naftalin RJ. A computer model simulating human glucose absorption and metabolism in health and metabolic disease states. F1000Res. 2016 Apr 12;5:647. doi: 10.12688/f1000research.8299.1. eCollection 2016.
- Background Roder PV, Geillinger KE, Zietek TS, Thorens B, Koepsell H, Daniel H. The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014 Feb 26;9(2):e89977. doi: 10.1371/journal.pone.0089977. eCollection 2014.
- Background Russell M, Rees G, Benton D, Kingsley M. An exercise protocol that replicates soccer match-play. Int J Sports Med. 2011 Jul;32(7):511-8. doi: 10.1055/s-0031-1273742. Epub 2011 Apr 6.
- Background Russell M, Benton D, Kingsley M. Influence of carbohydrate supplementation on skill performance during a soccer match simulation. J Sci Med Sport. 2012 Jul;15(4):348-54. doi: 10.1016/j.jsams.2011.12.006. Epub 2012 Jan 9.
- Background Russell M, Benton D, Kingsley M. Carbohydrate ingestion before and during soccer match play and blood glucose and lactate concentrations. J Athl Train. 2014 Jul-Aug;49(4):447-53. doi: 10.4085/1062-6050-49.3.12. Epub 2014 Jun 16.
- Background Russell M, Kingsley M. The efficacy of acute nutritional interventions on soccer skill performance. Sports Med. 2014 Jul;44(7):957-70. doi: 10.1007/s40279-014-0184-8.
- Background Seidelmann SB, Feofanova E, Yu B, Franceschini N, Claggett B, Kuokkanen M, Puolijoki H, Ebeling T, Perola M, Salomaa V, Shah A, Coresh J, Selvin E, MacRae CA, Cheng S, Boerwinkle E, Solomon SD. Genetic Variants in SGLT1, Glucose Tolerance, and Cardiometabolic Risk. J Am Coll Cardiol. 2018 Oct 9;72(15):1763-1773. doi: 10.1016/j.jacc.2018.07.061.
- Background Simulescu, V., Ilia, G., Macarie, L., & Merghes, P. (2019). Sport and energy drinks consumption before, during and after training. Science and Sports, 34(1), 3-9. https://doi.org/10.1016/j.scispo.2018.10.002
- Background Pfeiffer B, Stellingwerff T, Zaltas E, Jeukendrup AE. Oxidation of solid versus liquid CHO sources during exercise. Med Sci Sports Exerc. 2010 Nov;42(11):2030-7. doi: 10.1249/MSS.0b013e3181e0efc9.
- Background Thazhath SS, Wu T, Young RL, Horowitz M, Rayner CK. Glucose absorption in small intestinal diseases. Expert Rev Gastroenterol Hepatol. 2014 Mar;8(3):301-12. doi: 10.1586/17474124.2014.887439. Epub 2014 Feb 6.
- Background Thomas DT, Erdman KA, Burke LM. American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance. Med Sci Sports Exerc. 2016 Mar;48(3):543-68. doi: 10.1249/MSS.0000000000000852.
- Background Thorsen K, Drengstig T, Ruoff P. Transepithelial glucose transport and Na+/K+ homeostasis in enterocytes: an integrative model. Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C320-37. doi: 10.1152/ajpcell.00068.2013. Epub 2014 Jun 4.
- Background Scribbans TD, Vecsey S, Hankinson PB, Foster WS, Gurd BJ. The Effect of Training Intensity on VO2max in Young Healthy Adults: A Meta-Regression and Meta-Analysis. Int J Exerc Sci. 2016 Apr 1;9(2):230-247. doi: 10.70252/HHBR9374. eCollection 2016.
- Background Zisko N, Stensvold D, Hordnes-Slagsvold K, Rognmo O, Nauman J, Wisloff U, Karlsen T. Effect of Change in VO2max on Daily Total Energy Expenditure in a Cohort of Norwegian Men: A Randomized Pilot Study. Open Cardiovasc Med J. 2015 Apr 30;9:50-7. doi: 10.2174/1874192401509010050. eCollection 2015.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Dextrose | Unknown | 10 % | Oral |
| Subject | Dextrose | Unknown | 150 ml | Oral |
| Subject | Natrium Dextrose | Unknown | 10 % | Oral |
| Subject | Natrium Dextrose | Unknown | 20 ml | Oral |
| Subject | Natrium Dextrose | Unknown | 150 ml | Oral |
Indications
No indication recorded.