Pharmacokinetics, Subjective Effects, and Abuse Liability of Nicotine Salt-Based Vaping Products With Tobacco or Unflavored E-liquids, SALTVAPE Study

Summary

This trial studies activity of time (pharmacokinetics), subjective effects, and abuse liability of nicotine salt-based vaping products with tobacco or e-liquids. This study aims to determine and compare the levels of nicotine delivered to the bloodstream from nicotine salt and free-base nicotine e-liquid solutions.

Timeline

Start

2020-02-18

Primary completion

2024-07-10

Completion

2024-07-10

Publications

• Block AC, Martin CD, Leigh NJ, Page MK, Kaiser LM, Nardotto GHB, Rosario SR, Felicione NJ, O'Connor RJ, Goniewicz ML, Quisenberry AJ. Effects of nicotine form and tobacco flavor on pharmacokinetics, subjective effects, and behavioral indicators of abuse liability of e-cigarettes. Nicotine Tob Res. 2026 Mar 21:ntag058. doi: 10.1093/ntr/ntag058. Online ahead of print.

Drugs

Indications