Oral Vancomycin Versus Probiotics Versus Placebo for Prevention of Clostridium Difficile Infection in Colonized Patients

Summary

The goal of this pilot study is to assess the feasibility of randomizing hospitalized patients that are colonized with C. difficile and started on systemic antibiotics to either a probiotic, oral vancomycin, or placebo in a parallel-group 1:1:1 design. The ultimate goal is to conduct an appropriately-powered RCT to determine the optimal method for reducing C difficile infection in colonized patients.

Timeline

Start

2022-09-01

Primary completion

2024-09-12

Completion

2024-09-12

Outcome

Outcome not reported

Stopped (Enrollment): “No patients enrolled. Identification of patients in allocated timeframe was not feasible.”

Drugs

Indications