Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors

Summary

The goal of this proposal is to test the overall hypothesis that e-cigarettes (ECs) provide efficient nicotine delivery to the brain and arterial blood in non-EC-naïve smokers and e-cigarette users and that EC liquid characteristics modulate this effect. This study will test the hypothesis through complementary methods that include \[ \[18F\]NCFHEB (aka \[18F\]Flubatine) PET neuroimaging, arterial blood nicotine measurements, and subjective drug effects assessments.

Timeline

Start

2022-12-30

Primary completion

2024-02-01

Completion

2025-02-01

Drugs

Indications

No indication recorded.