The Interaction of Flavor With Nicotine Form in Adult Smokers

Summary

This study seeks to elucidate the impact of e-cigarette flavor on subjective effects and nicotine exposure from e-cigarettes containing different forms of nicotine.

Timeline

Start

2020-11-01

Primary completion

2022-01-10

Completion

2022-02-02

Outcome

Mixed primary results

registry LEAST_SQUARES_MEAN Overall Participants: Nicotine Salt: 14.2 (Standard Error 6.0) score on a scale NCT04262817 ↗

registry LEAST_SQUARES_MEAN Overall Participants: Freebase Nicotine: 5.3 (Standard Error 6.6) score on a scale NCT04262817 ↗

registry analysis (superiority test); Overall Participants; p = 0.01; Mixed Models Analysis NCT04262817 ↗

registry analysis (superiority test); Overall Participants; p = 0.38; Mixed Models Analysis NCT04262817 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotine	Unknown	36 mg/ml	—

Indications