drugset / Trial / NCT04263454
The Innate Central Nervous System Immune Response to an Experimental Immune Challenge in People With Fibromyalgia
Phase 2/3
Completed
36 enrolled
University of Alabama at Birmingham
American Fibromyalgia Syndrome Association · collab
Non-randomizedParallel-groupTriple-blindOther
Summary
The major goal of this study is to determine if the innate immune response is dysregulated in people with fibromyalgia, compared to healthy controls. Magnetic resonance spectroscopy will be used to measure changes in the brain's metabolic profile following an experimental immune stimulus, to test whether individuals with fibromyalgia show a heightened immune response in the brain. The ultimate goal of this research is to better understand the role of brain inflammation in the pathophysiology of chronic pain and fatigue, which will guide the development of more effective therapies for these conditions.
Timeline
- Start
- 2020-03-11
- Primary completion
- 2021-12-22
- Completion
- 2021-12-22
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Endotoxin, Escherichia Coli | Unknown | 0.3 ng | Intravenous |
| Subject | Endotoxin, Escherichia Coli | Unknown | 0.4 ng | Intravenous |