drugset / Trial / NCT04264676
Study of Oral Metronidazole on Postoperative Chemotherapy in Colorectal Cancer
Phase 2
Unknown
294 enrolled
Shanghai Jiao Tong University School of Medicine
Fudan University · collabRuijin Hospital · collabShanghai Municipal Commission of Health and Family Planning · collabShanghai Shen Kang Hospital Development Center · collabShanghai Zhongshan Hospital · collab
RandomizedParallel-groupQuadruple-blindTreatment
Summary
Fusobacterium nucleatum (Fusobacterium nucleatum, Fn) has been identified as an independent risk factor for recurrence of colorectal cancer. In this study, oral metronidazole would be used to reduce the abundance of Fn in patients with high Fn, so as to explore whether oral metronidazole can improve the efficacy of postoperative chemotherapy in patients with colorectal cancer.
Timeline
- Start
- 2020-03-31
- Primary completion
- 2023-03
- Completion
- 2025-03
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Metronidazole | Small molecule | 0.4 g | Oral |