Novel Insight Into Migraine Pathophysiolgy and Galcanezumab Mechanisms of Action

Summary

The purpose of this study is to understand better the mechanisms of action of calcitonin gene related peptide (CGRP) targeted monoclonal antibodies in migraine prevention. Specifically, the protocol will allow the investigators to determine whether the main site of action of this novel and recently-approved class of migraine prophylactic drugs act inside or outside the brain and if so, where.

Timeline

Start

2020-07-29

Primary completion

2023-11-22

Completion

2023-11-22

Publications

• Ashina S, Melo-Carrillo A, Toluwanimi A, Bolo N, Szabo E, Borsook D, Burstein R. Galcanezumab effects on incidence of headache after occurrence of triggers, premonitory symptoms, and aura in responders, non-responders, super-responders, and super non-responders. J Headache Pain. 2023 Mar 16;24(1):26. doi: 10.1186/s10194-023-01560-x.

Drugs

Indications