The Effects of a Single Dose of Methylphenidate on Motor Performance

Summary

Aim: To evaluate the effects of MPH on young adults diagnosed with ADHD on different exercise performance tests. Hypothesis: MPH will have positive effects on motor tests requiring concentration. Methods: 200 healthy physical education students, 100 participants diagnosed with ADHD will serve as the treatment group and 100 non-ADHD diagnosed will serve as a control group. The study will be divided into two sub studies (100 participants each), in which, two motor tests will be evaluated (two agility tests, two motor accuracy tests and balance). All participants will arrive for two sessions, and will perform two motor tests in each session. In the second session, half of the participants with ADHD (25 participants) will undergo another session of the same motor tests with their usual treatment (treatment group) and another half (25 participants) without their treatment (ADHD control group). The non-ADHD control group (50 participants) will perform the second session without medications - to assess a learning effect. Note, the investigators are not planning on giving the medication to the participant, rather he/she will consume their own prescribed MPH by them self. Control treatment for ADHD participants will consist of not taking their medication before the motor test. For evaluation of physiological responses and perception of effort, heart rate, temperature, blood pressure and RPE before and after motor tests, will be measured.

Timeline

Start

2021-05-27

Primary completion

2024-03

Completion

2024-03

Publications

• Background Battle DE. Diagnostic and Statistical Manual of Mental Disorders (DSM). Codas. 2013;25(2):191-2. doi: 10.1590/s2317-17822013000200017. No abstract available.
• Background Huss M, Duhan P, Gandhi P, Chen CW, Spannhuth C, Kumar V. Methylphenidate dose optimization for ADHD treatment: review of safety, efficacy, and clinical necessity. Neuropsychiatr Dis Treat. 2017 Jul 4;13:1741-1751. doi: 10.2147/NDT.S130444. eCollection 2017.
• Background Zimmer L. Contribution of Clinical Neuroimaging to the Understanding of the Pharmacology of Methylphenidate. Trends Pharmacol Sci. 2017 Jul;38(7):608-620. doi: 10.1016/j.tips.2017.04.001. Epub 2017 Apr 24.
• Background Shorer Z, Bachner Y, Guy T, Melzer I. Effect of single dose methylphenidate on walking and postural stability under single- and dual-task conditions in older adults--a double-blind randomized control trial. J Gerontol A Biol Sci Med Sci. 2013 Oct;68(10):1271-80. doi: 10.1093/gerona/glt035. Epub 2013 Apr 11.
• Background Ben-Itzhak R, Giladi N, Gruendlinger L, Hausdorff JM. Can methylphenidate reduce fall risk in community-living older adults? A double-blind, single-dose cross-over study. J Am Geriatr Soc. 2008 Apr;56(4):695-700. doi: 10.1111/j.1532-5415.2007.01623.x. Epub 2008 Feb 7.
• Background Cordeiro LMS, Rabelo PCR, Moraes MM, Teixeira-Coelho F, Coimbra CC, Wanner SP, Soares DD. Physical exercise-induced fatigue: the role of serotonergic and dopaminergic systems. Braz J Med Biol Res. 2017 Oct 19;50(12):e6432. doi: 10.1590/1414-431X20176432.
• Background King M, Rauch LHG, Brooks SJ, Stein DJ, Lutz K. Methylphenidate Enhances Grip Force and Alters Brain Connectivity. Med Sci Sports Exerc. 2017 Jul;49(7):1443-1451. doi: 10.1249/MSS.0000000000001252.
• Background Swart J, Lamberts RP, Lambert MI, St Clair Gibson A, Lambert EV, Skowno J, Noakes TD. Exercising with reserve: evidence that the central nervous system regulates prolonged exercise performance. Br J Sports Med. 2009 Oct;43(10):782-8. doi: 10.1136/bjsm.2008.055889. Epub 2008 Dec 3.
• Background Roelands B, Hasegawa H, Watson P, Piacentini MF, Buyse L, De Schutter G, Meeusen RR. The effects of acute dopamine reuptake inhibition on performance. Med Sci Sports Exerc. 2008 May;40(5):879-85. doi: 10.1249/MSS.0b013e3181659c4d.
• Background Marcora S. Can Doping be a Good Thing? Using Psychoactive Drugs to Facilitate Physical Activity Behaviour. Sports Med. 2016 Jan;46(1):1-5. doi: 10.1007/s40279-015-0412-x. No abstract available.
• Background Stray LL, Ellertsen B, Stray T. Motor function and methylphenidate effect in children with attention deficit hyperactivity disorder. Acta Paediatr. 2010 Aug;99(8):1199-204. doi: 10.1111/j.1651-2227.2010.01760.x. Epub 2010 Mar 12.
• Background Klass M, Roelands B, Levenez M, Fontenelle V, Pattyn N, Meeusen R, Duchateau J. Effects of noradrenaline and dopamine on supraspinal fatigue in well-trained men. Med Sci Sports Exerc. 2012 Dec;44(12):2299-308. doi: 10.1249/MSS.0b013e318265f356.
• Background Kang KD, Yun SW, Chung U, Kim TH, Park JH, Park IH, Han DH. Effects of methylphenidate on body index and physical fitness in Korean children with attention deficit hyperactivity disorder. Hum Psychopharmacol. 2016 Mar;31(2):76-82. doi: 10.1002/hup.2514. Epub 2016 Jan 12.
• Background Bart O, Daniel L, Dan O, Bar-Haim Y. Influence of methylphenidate on motor performance and attention in children with developmental coordination disorder and attention deficit hyperactive disorder. Res Dev Disabil. 2013 Jun;34(6):1922-7. doi: 10.1016/j.ridd.2013.03.015. Epub 2013 Apr 10.
• Background Meckel Y, Nemet D, Eliakim A. the Effect of Methylphenidate Treatment on Exercise Performance in Children With Attention-Deficit Hyperactivity Disorder. Acta Kinesiol. Univ. Tartu 7:109-16, 2011
• Background De Crescenzo F, Armando M, Mazzone L, Ciliberto M, Sciannamea M, Figueroa C, Janiri L, Quested D, Vicari S. The use of actigraphy in the monitoring of methylphenidate versus placebo in ADHD: a meta-analysis. Atten Defic Hyperact Disord. 2014 Mar;6(1):49-58. doi: 10.1007/s12402-013-0122-x. Epub 2013 Nov 28.
• Background Edvinsson D, Ekselius L. Long-Term Tolerability and Safety of Pharmacological Treatment of Adult Attention-Deficit/Hyperactivity Disorder: A 6-Year Prospective Naturalistic Study. J Clin Psychopharmacol. 2018 Aug;38(4):370-375. doi: 10.1097/JCP.0000000000000917.
• Background Zohar AH, Konfortes H. Diagnosing ADHD in Israeli adults: the psychometric properties of the adult ADHD Self Report Scale (ASRS) in Hebrew. Isr J Psychiatry Relat Sci. 2010;47(4):308-15.
• Background Mirkov D, Nedeljkovic A, Kukolj M, Ugarkovic D, Jaric S. Evaluation of the reliability of soccer-specific field tests. J Strength Cond Res. 2008 Jul;22(4):1046-50. doi: 10.1519/JSC.0b013e31816eb4af.
• Background Masuda S, Suganuma K, Kaneko C, Hoshina K, Suzuki T, Serita T, Sakakibara R. Prediction of Falls Using a 3-m Zigzag Walk Test. J Phys Ther Sci. 2013 Sep;25(9):1051-4. doi: 10.1589/jpts.25.1051. Epub 2013 Oct 20.
• Background Aquino R, Palucci Vieira LH, de Paula Oliveira L, Cruz Goncalves LG, Pereira Santiago PR. Relationship between field tests and match running performance in high-level young Brazilian soccer players. J Sports Med Phys Fitness. 2018 Mar;58(3):256-262. doi: 10.23736/S0022-4707.17.06651-8. Epub 2017 Feb 14.
• Background Archer DT, Drysdale K, Bradley EJ. Differentiating technical skill and motor abilities in selected and non-selected 3-5 year old team-sports players. Hum Mov Sci. 2016 Jun;47:81-87. doi: 10.1016/j.humov.2016.02.001. Epub 2016 Feb 22.
• Background Pojskic H, Muratovic M. The relationship between physical fitness and shooting accuracy of professional basketball players 20:1-13, 2014
• Background Borg GA. Perceived exertion. Exerc Sport Sci Rev. 1974;2:131-53. No abstract available.

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