drugset / Trial / NCT04293042

Treatment of BK Virus Infection With CTL Cells in Immunocompromised Transplant Patients

NCT04293042 ↗

Phase 0 Recruiting 20 enrolled Children's Hospital of Philadelphia
NaSingle-groupOpen-labelSupportive care

Summary

This is a pilot study using cytotoxic T lymphocytes (CTLs) manufactured with the Miltenyi CliniMACS Prodigy Gamma-capture system will be effective in decreasing specific viral load in patients with BK virus viremia and BK virus-associated symptoms post-allogeneic hematopoietic stem cell transplantation (HSCT), renal transplantation, and chemotherapy.

Timeline

Start
2019-10-07
Primary completion
2028-01-30
Completion
2029-01-30

Drugs

EvaluationDrugModalityDoseRoute
Subject BK-virus specific CTLs Cell therapy 5000 cells/kg Intravenous
Subject BK-virus specific CTLs Cell therapy 25000 cells/kg Intravenous