drugset / Trial / NCT04299971

Efficiency of Methotrexate and Tofacitinib in Mild and Moderate Patients

NCT04299971

Phase 4 Unknown 130 enrolled Shanghai Zhongshan Hospital
RandomizedCrossoverOpen-labelTreatment

Summary

Takayasu arteritis (TAK) is a rare chronic inflammatory arteritis, which lacks an effective well-accepted intervention strategy. Here we tried to classify TAK patients in 3 levels, including mild, moderate, and severe, and prescribe methotrexate and tofacitinib randomly in mild and moderate patients, to observe the relatively better treatment strategy, facilitating better intervention strategy in TAK patients.

Timeline

Start
2020-03-01
Primary completion
2022-12-31
Completion
2023-12-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Methotrexate Small molecule 15 mg Oral
Subject Tofacitinib Small molecule 5 mg Oral

Indications