drugset / Trial / NCT04300192
Study to Evaluate the Immune Response After Booster Vaccination With Tdap-IPV Vaccine (Against Tetanus, Diphtheria, Pertussis and Poliomyelitis) in Children Who Received Different Pertussis Primary Vaccine Regimens in Republic of South Africa
Non-randomizedParallel-groupOpen-labelPrevention
Summary
Primary Objectives : * To describe the long-term humoral immune responses to pertussis, diphtheria, and tetanus after homologous and heterologous pertussis vaccine priming regimens * To determine the effects of the priming regimen on humoral responses to booster vaccination with Tdap-IPV vaccine * To describe the long-term cell-mediated immune responses to pertussis after homologous and heterologous pertussis vaccine priming regimens * To determine the effects of the priming regimen on cell-mediated immune response to booster vaccination with Tdap-IPV vaccine Secondary Objective: To describe the safety profile of Tdap-IPV vaccine in each group
Timeline
- Start
- 2021-01-27
- Primary completion
- 2023-01-11
- Completion
- 2023-01-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | TDaP-IPV vaccine | Vaccine | — | Intramuscular |