Opioid, HIV and Immune System

Summary

The purpose of this research is to evaluate blood samples from HIV infected and non-HIV infected people opioid and non opioid users to understand how opioid affect the immune responses (body defenses against infection) to the flu vaccine.

Timeline

Start

2020-11-18

Primary completion

2027-01-31

Completion

2027-12-31

Publications

• Background Ghanta PP, Dang CM, Nelson CM, Feaster DJ, Forrest DW, Tookes H, Pahwa RN, Pallikkuth S, Pahwa SG. Soluble Plasma Proteins of Tumor Necrosis Factor and Immunoglobulin Superfamilies Reveal New Insights into Immune Regulation in People with HIV and Opioid Use Disorder. Vaccines (Basel). 2024 May 9;12(5):520. doi: 10.3390/vaccines12050520.
• Background Dang CM, Nelson CM, Feaster DJ, Kizhner A, Forrest DW, Nakamura N, Iyer A, Ghanta PP, Jayaweera DT, Rodriguez AE, Pahwa RN, Tookes HE, Pallikkuth S, Pahwa SG. Opioids exacerbate inflammation in people with well-controlled HIV. Front Immunol. 2023 Nov 1;14:1277491. doi: 10.3389/fimmu.2023.1277491. eCollection 2023.
• Background Dang CM, Nelson CM, Pahwa RN, Tookes HE, Feaster DJ, Singh P, Rodriguez AE, Forrest DW, Nakamura N, Ghanta PP, Jayaweera DT, Iyer A, Pallikkuth S, Pahwa SG. Chronic opioid use is associated with higher antibody response to influenza vaccination in people living with HIV. Front Immunol. 2025 Dec 17;16:1686103. doi: 10.3389/fimmu.2025.1686103. eCollection 2025.

Drugs

Indications