Clinical Trial of Sintilimab Combined With Gemcitabine/Carboplatin Regimen in the Treatment of Advanced Primary Pulmonary Lymphoepithelioma-like Carcinoma

Summary

The trial was designed to explore the safety and efficacy of sintilimab combined with gemcitabine and carboplatin in the treatment of advanced LELC.

Timeline

Start

2020-03

Primary completion

2021-08

Completion

2022-08

Publications

• Lin X, Deng H, Fang N, Chen L, Chen R, Xie X, Xie Z, Zhang J, Liu M, Liu L, Sun N, Wang F, Yang Y, Lv X, Zhang Z, Cai S, Hou T, Li S, He J, Zhou C. Sintilimab plus chemotherapy for first-line treatment of advanced pulmonary lymphoepithelioma-like carcinoma: Phase 2 trial. Cell Rep Med. 2025 Oct 21;6(10):102398. doi: 10.1016/j.xcrm.2025.102398. Epub 2025 Oct 6.

Drugs

Indications