drugset
drugset / Trial / NCT04316091

A Phase I Clinical Trial of Neoadjuvant Chemotherapy With/Without SPIONs/SMF for Patients With Osteosarcoma

NCT04316091 ↗

Phase 1 Unknown 60 enrolled Second Affiliated Hospital, School of Medicine, Zhejiang University Leiden University Medical Center · collab
Non-randomizedParallel-groupOpen-labelTreatment

Summary

Osteosarcoma is the most common primary malignant bone tumor that mainly occurs in children and adolescents. Combined surgical resection and intensive chemotherapy has improved the 5-year overall survival rate (from 51 to 75%). However, drug-induced side effects and tumor recurrence after surgery reduce patient quality of life and cut down the patient survival rate. Superparamagnetic Iron Oxide Nanoparticles (SPIONs)/Spinning Magnetic Field (SMF) and neoadjuvant chemotherapy may increase the cancer cell killing and complete tumor shrinkage preserving local structures and functions of patients who cannot receive limb retention treatment.

Timeline

Start
2020-09-01
Primary completion
2021-08-31
Completion
2023-08-31

Drugs

EvaluationDrugModalityDoseRoute
Subject SPIONs Unknown — Other

Indications

bone osteosarcoma