Twice Weekly Steroids and Exercise as Therapy for DMD

Summary

The study team will determine the potential of low dose twice weekly prednisone and whether exercise training can synergize to delay disease progression and improve muscle strength/physical function in boys with Duchenne muscular dystrophy (DMD). Current standard of care (daily prednisone) is associated with adverse side effects. Evidence from DMD mouse models suggest that weekly dosing provides same efficacy without side effects. Appropriate exercise may also benefit but this area has not been adequately explored.

Timeline

Start

2020-07-30

Primary completion

2024-12-04

Completion

2025-09-04

Drugs

Indications