drugset / Trial / NCT04325776
A Study of AL2846 Versus Zoledronic Acid in Subjects With Advanced Non-Small Cell Lung Cancer With Bone Metastasis
RandomizedParallel-groupQuadruple-blindTreatment
Summary
AL2846 is a multi-target tyrosine kinase receptor inhibitor with obvious selective to c-met, suggesting that its anti-tumor effect mainly inhibits the activation of key downstream oncogenic pathways by inhibiting expression of c-met, tumor angiogenesis and tumor cell migration.
Timeline
- Start
- 2020-09-24
- Primary completion
- 2021-05
- Completion
- 2021-11
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | AL2846 | Small molecule | 150 mg | Oral |
| Comparator | Zoledronic acid | Other / unclassified | 4 mg | Intravenous |