Talazoparib and Axitinib for People With Previously Treated Advanced Kidney Cancer

Summary

Researchers are doing this study to find out if the combination of the drugs axitinib and talazoparib is a safe and effective treatment for people with your previously treated advanced kidney cancer. Researchers will look for the highest dose of talazoparib that causes few or mild side effects when given in combination with a standard dose of axitinib.

Timeline

Start

2020-04-06

Primary completion

2025-05-23

Completion

2025-05-23

Publications

• Background Kotecha RR, Doshi SD, Knezevic A, Jacobi R, Woo HJ, Aggen DH, McHugh DJ, Shah NJ, Carlo MI, Keegan NM, Gayadin Y, Chaim J, Donoghue MTA, Iyer G, Lee CH, Feldman DR, Motzer RJ, Voss MH. A Phase 1b/2 Study of Talazoparib and Axitinib in Patients with Advanced Clear-cell Renal Cell Carcinoma. Eur Urol Oncol. 2025 Aug;8(4):866-870. doi: 10.1016/j.euo.2025.03.010. Epub 2025 Mar 29.

Drugs

Indications