drugset / Trial / NCT04352465
Efficacy and Safety of MTX-loaded Nanoparticles to Treat Severe COVID-19 Patients
Phase 1/2
Unknown
42 enrolled
Azidus Brasil
Hospital Santa Marcelina · collabInCor Heart Institute · collabPrevent Senior Institute · collab
Non-randomizedSequentialOpen-labelTreatment
Summary
The aim of this study is to evaluate the efficacy and safety of MTX-loaded nanoparticles in three different doses to treat severe COVID-19 patients.
Timeline
- Start
- 2020-05-01
- Primary completion
- 2020-06-30
- Completion
- 2020-11-30
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methotrexate | Small molecule | 20 mg | Intravenous |
| Subject | Methotrexate | Small molecule | 30 mg | Intravenous |
| Subject | Methotrexate | Small molecule | 40 mg | Intravenous |