drugset / Trial / NCT04353362

Alternative Antibiotic Regimen in Periodontitis Treatment

NCT04353362

Phase 4 Completed 74 enrolled Istanbul Medipol University Hospital
RandomizedParallel-groupDouble-blindSupportive care

Summary

Context and Aims: Several studies have demonstrated an association between obesity, periodontitis, and exercise. This study aimed to investigate the effects of regular exercise on obese women with periodontal disease, using serum, saliva, and gingival crevicular fluid (GCF) samples. Settings and Design: A before-after study design was adopted to evaluate the effects of 12 weeks of regular exercise on obese women grouped according to periodontal status, without a control group (no exercise). Methods and Material: The study sample comprised fifteen patients without periodontitis (NP group) and 10 patients with chronic periodontitis (CP group), from whom periodontal parameters were measured and serum, saliva, and GCF samples were collected. Body mass index (BMI), anthropometric measurements, somatotype-motoric tests, and maximal oxygen consumption (VO2max) were recorded at baseline and after exercise. Statistical analysis used: MedCalc was used for statistical analysis.

Timeline

Start
2017-04-01
Primary completion
2020-01-02
Completion
2020-03-10

Drugs

EvaluationDrugModalityDoseRoute
Comparator Amoxicillin Other / unclassified 500 mg
Comparator Metronidazole Small molecule 500 mg
Subject Ofloxacin Small molecule 400 mg

Indications