drugset / Trial / NCT04358471

Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA)

NCT04358471

Phase 2 Withdrawn Hemera Biosciences
RandomizedParallel-groupDouble-blindTreatment

Summary

Patients with advanced dry AMD with GA meeting inclusion criteria will be randomized in one eye in a 1:1:1 ratio comparing intravitreal high or low dose AAVCAGsCD59 with a sham injection. All enrolled subjects will be followed for 24 months to evaluate reduction in GA growth and safety of intravitreal AAVCAGsCD59.

Timeline

Start
2021-07-31
Primary completion
2023-07-01
Completion
2023-09-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator AAVCAGsCD59 Gene therapy (AAV / viral vector) 3.56e+11 vg Intravitreal
Comparator AAVCAGsCD59 Gene therapy (AAV / viral vector) 1.071e+12 vg Intravitreal