drugset / Trial / NCT04358471
Intravitreal AAVCAGsCD59 for Advanced Dry Age-related Macular Degeneration (AMD) With Geographic Atrophy (GA)
RandomizedParallel-groupDouble-blindTreatment
Summary
Patients with advanced dry AMD with GA meeting inclusion criteria will be randomized in one eye in a 1:1:1 ratio comparing intravitreal high or low dose AAVCAGsCD59 with a sham injection. All enrolled subjects will be followed for 24 months to evaluate reduction in GA growth and safety of intravitreal AAVCAGsCD59.
Timeline
- Start
- 2021-07-31
- Primary completion
- 2023-07-01
- Completion
- 2023-09-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | AAVCAGsCD59 | Gene therapy (AAV / viral vector) | 3.56e+11 vg | Intravitreal |
| Comparator | AAVCAGsCD59 | Gene therapy (AAV / viral vector) | 1.071e+12 vg | Intravitreal |