drugset / Trial / NCT04365153

Canakinumab in Covid-19 Cardiac Injury (The Three C Study)

NCT04365153

Phase 2 Completed 45 enrolled The Cleveland Clinic Novartis · collab
RandomizedParallel-groupQuadruple-blindTreatment

Summary

TThe purpose of this prospective, Phase 2, single center, blinded, randomized controlled study is to demonstrate as a proof of concept that early treatment with canakinumab prevents progressive heart and respiratory failure in patients with COVID-19 infection. These results will lead to and inform a Phase III randomized placebo-controlled trial.

Timeline

Start
2020-04-24
Primary completion
2021-02-02
Completion
2021-04-01

Drugs

EvaluationDrugModalityDoseRoute
Comparator Canakinumab Monoclonal antibody 300 mg Intravenous
Comparator Canakinumab Monoclonal antibody 600 mg Intravenous

Indications