Pilot Study on Withdrawal of Spironolactone Among Heart Failure With Improved Ejection Fraction

Summary

The study is a randomized controlled pilot trial to evaluate whether withdrawal of spironolactone is safe and associated with re-deterioration of left ventricular function in patients with heart failure with improved ejection fraction. The aim of current trial is to test the hypothesis that withdrawal of spironolactone would not be associated with relapse of significant clinical deterioration of left ventricular systolic function.

Timeline

Start

2020-08-13

Primary completion

2021-12-10

Completion

2022-06-30

Publications

• Hyun J, Lee SA, Lee SE, Hong JA, Kim MS, Kim JJ. Withdrawal of Spironolactone for Heart Failure With Improved Ejection Fraction: An Open-Label, Pilot, Randomized Controlled Trial (With-HF Trial). Korean Circ J. 2025 Dec;55(12):1077-1089. doi: 10.4070/kcj.2025.0052. Epub 2025 Jul 8.

Drugs

Indications