High Dose Oral Omeprazole in High Risk UGIB

Summary

Peptic ulcer bleeding is the most common etiology in upper gastrointestinal bleeding all over the world. After endoscopic treatment, proton pump inhibitor (PPI) is recommended to prevent re-bleeding. Intravenous PPI is recommended as a standard treatment. In the past, there were many trials showing the efficacy of high-dose oral PPI after endoscopic hemostasis but most were industrial sponsor which assessing an expensive PPI. Moreover, the number of patients in those studies were insufficient to confirm a non-inferiority outcome in term of rebleeding by using oral PPI. This study will evaluate a high-dose, local-made PPI (omeprazole) in peptic ulcer treatment after successful endoscopic hemostasis compared to standard IV PPI continuous drip in term of rebleeding, as well as 24-hour gastric pH monitoring.

Timeline

Start

2020-10-01

Primary completion

2025-05-30

Completion

2025-12-31

Publications

• Sriyudthsak K, Nalinthassanai N, Sriapiraksa B, Rattanachaisit P, Patcharatrakul T, Pittayanon R. High-Dose Oral Omeprazole Versus Continuous Intravenous Pantoprazole in Patients With High-Risk Peptic Ulcer Bleeding: A Single-Blinded Multicenter RCT. J Gastroenterol Hepatol. 2026 Jul 12. doi: 10.1111/jgh.70566. Online ahead of print.

Drugs

Indications

No indication recorded.