drugset / Trial / NCT04399525
Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
RandomizedCrossoverDouble-blindBasic science
Summary
In order to validate the accuracy and reliability of the histamine skin prick model for histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine skin prick will be evaluated after the administration of certain H1-antihistamines. Besides, the influence of these H1-antihistamines on the dermal blood flow response induced by the topical application of cinnamaldehyde and capsaicin will be evaluated. Changes in dermal blood flow will be measured with laser speckle contrast imaging.
Timeline
- Start
- 2019-10-28
- Primary completion
- 2020-03-12
- Completion
- 2020-03-12
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Desloratadine | Small molecule | 5 mg | Oral |
| Subject | Desloratadine | Small molecule | 10 mg | Oral |
| Subject | Levocetirizine | Unknown | 5 mg | Oral |
| Subject | Levocetirizine | Unknown | 10 mg | Oral |
Indications
No indication recorded.