Nitrites, Skeletal Muscle Mitochondrial Bioenergetics, and Physical Activity in Old Age

Summary

This 2-site randomized double blinded controlled trial is to confirm and more definitively clarify the impact of a 12-week course of nitrite versus placebo on mitochondrial bioenergetics in older sedentary adults. This investigator will take an integrative physiology approach to determine the effect of nitrite therapy on a comprehensive assessment of mitochondrial energetics, skeletal muscle vascular function, and whole body physical function (cardiorespiratory function, exercise endurance, strength, balance, and physical activity) and fatigability.

Timeline

Start

2021-04-23

Primary completion

2023-07-14

Completion

2023-07-14

Publications

• Forman DE, Perera S, Shiva S, Glynn NW, Stakich TS, Ramos SV, Distefano G, Wolf C, Kendi A, Sterczala AJ, Sipula IJ, Bello FM, Jurczak MJ, Sciurba FC, Gladwin MT, Newman AB, Coen PM. Benefits of oral nitrite supplementation on mitochondrial respiration and physical function in older adults. J Gerontol A Biol Sci Med Sci. 2026 Mar 10;81(4):glag034. doi: 10.1093/gerona/glag034.

Drugs

Indications

No indication recorded.