Allogeneic BM-MSCs in Patients with Lumbar Facet Arthropathy

Phase 1 Completed 10 enrolled Mayo Clinic

NaSingle-groupOpen-labelTreatment

Summary

Researchers are conducting this study to learn more about the side effects of bone marrow-derived stem cells when injected into the facet joints for the treatment of painful lumbar facet joint arthropathies.

Timeline

Start: 2020-04-28
Primary completion: 2024-03-15
Completion: 2024-03-15

Publications

Qu W, Yan D, Durand NC, Wang Z, Lehman VL, Osborne MD, Stone JA, Miller DA, Gupta S, Engelberg-Cook E, Wiest EF, Witter DM, Siebenaler KA, Quinones-Hinojosa A, Zubair AC. Intra-articular delivery of allogeneic bone marrow derived mesenchymal stromal cells (BM-MSCs) for painful lumbar facet arthropathy: a phase I clinical trial. Stem Cell Res Ther. 2025 Oct 30;16(1):596. doi: 10.1186/s13287-025-04674-y.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	BM-MSCs	Cell therapy	10 cells	Other

Indications

No indication recorded.