Evaluating the Benefits of Physiologic Insulin Delivery

Summary

In normal physiology insulin is secreted by beta cells into the portal vein. There have been a number of purported benefits among long-term intraperitoneal insulin users. In the present study we will inject ultra-rapid acting insulin into the upper and lower peritoneum under ultrasound guidance and compare it to subcutaneous injection. We will measure glucose, insulin and glucagon following these injections, to assess for benefits in counter-regulatory hormone production and insulin pharmacokinetics.

Timeline

Start

2021-11-01

Primary completion

2023-06-02

Completion

2023-06-02

Drugs

Indications