RAS and Coagulopathy in COVID19

Summary

To determine whether the coagulopathy associated with COVID-19 infection is driven by overactivation of the renin angiotensin system (RAS)

Timeline

Start

2020-10-09

Primary completion

2021-05-12

Completion

2021-05-12

Publications

• Results Robbins AJ, Che Bakri NA, Toke-Bjolgerud E, Edwards A, Vikraman A, Michalsky C, Fossler M, Lemm NM, Medhipour S, Budd W, Gravani A, Hurley L, Kapil V, Jackson A, Lonsdale D, Latham V, Laffan M, Chapman N, Cooper N, Szydlo R, Boyle J, Pollock KM, Owen D. The effect of TRV027 on coagulation in COVID-19: A pilot randomized, placebo-controlled trial. Br J Clin Pharmacol. 2023 Apr;89(4):1495-1501. doi: 10.1111/bcp.15618. Epub 2022 Dec 14.

Drugs

Indications