Bone Marrow Mesenchymal Stem Cells Transfer in Patients With ST-segment Elevation Myocardial Infarction

Phase 2/3 Completed 43 enrolled Afﬁliated Hospital of North Sichuan Medical College Beijing Tongren Hospital · collab Chinese PLA General Hospital · collab Peking Union Medical College Hospital · collab

RandomizedParallel-groupSingle-blindTreatment

Summary

To investigate the effect and safety of intracoronary autologous bone morrow mesenchymal stem cells (BM-MSCs) transplantation in patients with ST-segment elevation myocardial infarction（ STEMI） .

Timeline

Start: 2008-05-01
Primary completion: 2010-07-10
Completion: 2011-07-15

Outcome

Missed primary endpoint

paper there was no statistically significant difference between the two groups in the change of myocardial perfusion defect index (p = 0.37) PMID 33413636 ↗

paper However, there was no statistically significant difference between the two groups in the change of the LVEF (p = 0.23). PMID 33413636 ↗

Publications

Zhang R, Yu J, Zhang N, Li W, Wang J, Cai G, Chen Y, Yang Y, Liu Z. Bone marrow mesenchymal stem cells transfer in patients with ST-segment elevation myocardial infarction: single-blind, multicenter, randomized controlled trial. Stem Cell Res Ther. 2021 Jan 7;12(1):33. doi: 10.1186/s13287-020-02096-6.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Bone marrow mesenchymal stem cells	Cell therapy	—	Other