Oxytocin Pharmacokinetics After Intramuscular Injection

Summary

In this study people with knee arthritis so severe that a joint replacement is needed are recruited for a one day study. Study participants will have an intravenous catheter (IV) inserted in the forearm. A single intramuscular (IM) injection of oxytocin (Pitocin®), 17 micrograms will be administered and blood samples will be taken several times over the next 120 minutes. The amount of oxytocin will be measured in the blood samples. The main purpose of this study is to sample the blood, before and after the administration of oxytocin and calculate the pharmacokinetics (amount of oxytocin in the blood over time) of oxytocin.

Timeline

Start

2021-12

Primary completion

2022-06

Completion

2022-12

Outcome

Outcome not reported

Stopped (Enrollment): “Study was not initiated; no subjects were consented or enrolled”

Drugs

Indications