Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia

Phase 0 Completed 21 enrolled Mclean Hospital National Institute on Aging (NIA) · collab

NaSingle-groupOpen-labelBasic science

Summary

The primary aim of this study is to investigate the effects of exogenously administered nicotinamide riboside (NR) on brain energy metabolism, oxidative stress, and cognitive function in individuals with mild cognitive impairment (MCI) and mild Alzheimer's dementia (AD).

Timeline

Start: 2022-03-02
Primary completion: 2026-04-29
Completion: 2026-04-29

Publications

Zhang SQ, Lee J, Pan JP, Enger R, Hrubos-Strom H, Musiek ES, Fang EF, Le W. NAD+-circadian rhythm coupling in dementia. Alzheimers Dement. 2026 May;22(5):e71360. doi: 10.1002/alz.71360.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotinamide riboside	Small molecule	1000 mg	Oral

Effects of Nicotinamide Riboside on Bioenergetics and Oxidative Stress in Mild Cognitive Impairment/Alzheimer's Dementia

Summary

Timeline

Publications

Drugs

Indications