Effect of Dupilumab on Aspirin Intolerance

Summary

To test the efficacy of dupilumab in patients with AERD regarding the intolerance to salicylic acid after 6 months. This will be evaluated by oral drug provocation testing with low dose salicylic acid after 6 months of dupilumab treatment. Hypothesis: After 6 months of therapy, patients will tolerate aspirin dose levels as tested with different dosages (125mg, 250mg and 500 mg).

Timeline

Start

2020-06-01

Primary completion

2022-12-31

Completion

2022-12-31

Publications

• Eckl-Dorna J, Morgenstern C, Poglitsch K, Arnoldner T, Gangl K, Bartosik TJ, Campion NJ, Tu A, Stanek V, Schneider S, Bangert C. Dupilumab Dampens Mucosal Type 2 Response During Acetylsalicylic Acid Challenge in N-ERD Patients. Clin Exp Allergy. 2026 Mar;56(3):227-242. doi: 10.1111/cea.70184. Epub 2025 Nov 27.

Drugs

Indications