drugset / Trial / NCT04443608
Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management
RandomizedParallel-groupQuadruple-blindTreatment
Summary
When a patient arrives to an emergency department and is found to have an elevated potassium level in the blood, there is no one standardized treatment, therefore it is not known if one treatment is superior to other. The purpose of this study is to help determine if a drug called patiromer (already approved by the FDA) can help lower potassium levels while patients are in the emergency department.
Timeline
- Start
- 2020-10-08
- Primary completion
- 2023-03-09
- Completion
- 2023-06-03
Outcome
Outcome not reported
Stopped (Enrollment): “Recruitment window ended”
Publications
- Rafique Z, Safdar B, Duanmu Y, Boone S, Meltzer A, Bischof JJ, Robinson D, Budden J, Budd J, Quinn CM, Milliet C, Singer AJ, Soto K, Peacock F. Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): a randomised controlled trial in the emergency department. BMJ Open. 2026 Feb 23;16(2):e105103. doi: 10.1136/bmjopen-2025-105103.
- Rafique Z, Budden J, Quinn CM, Duanmu Y, Safdar B, Bischof JJ, Driver BE, Herzog CA, Weir MR, Singer AJ, Boone S, Soto-Ruiz KM, Peacock WF. Patiromer utility as an adjunct treatment in patients needing urgent hyperkalaemia management (PLATINUM): design of a multicentre, randomised, double-blind, placebo-controlled, parallel-group study. BMJ Open. 2023 Jun 12;13(6):e071311. doi: 10.1136/bmjopen-2022-071311.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Patiromer | Other / unclassified | 8.4 g | Oral |
Indications
No indication recorded.