drugset / Trial / NCT04450836

Sequences Of REGorafenib And Trifluridine/Tipiracil in Patients With Metastatic Colorectal Cancer

NCT04450836 ↗

Phase 2 Terminated 234 enrolled UNICANCER
RandomizedParallel-groupOpen-labelTreatment

Summary

A randomized, phase II study comparing the sequences of regorafenib and trifluridine/tipiracil, after failure of standard therapies in patients with metastatic colorectal cancer

Timeline

Start
2020-11-23
Primary completion
2024-03-23
Completion
2024-12-31

Outcome

Outcome not reported

Stopped: “Following the presentation of the SUNLIGHT study results at ASCO GI and the rapid change in patient management in the majority of centers, the IDMC experts recommended halting inclusion in the SOREGATT study with immediate effect.”

Drugs

EvaluationDrugModalityDoseRoute
Subject Regorafenib Small molecule 160 mg —
Subject Trifluridine/Tipiracil Unknown 35 mg/m2 Oral

Indications