drugset / Trial / NCT04457180
A Pharmacokinetic Interaction Study Between Apatinib Mesylate and Repaglinide or Bupropion in Advanced Solid Tumor Subjects
NaSingle-groupOpen-labelTreatment
Summary
The primary objective of the study was to assess investigate the pharmacokinetic effects of Apatinib Mesylate on CYP2C8 Substrate Repaglinide or CYP2B6 Substrate Bupropion and metabolite Hydroxy bupropion in Advanced solid tumor subjects. The secondary objective of the study was to assess the safety of Apatinib or/and Repaglinide and Bupropion.
Timeline
- Start
- 2020-11-16
- Primary completion
- 2021-05-20
- Completion
- 2021-06-19
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Bupropion | Small molecule | — | Oral |
| Subject | Repaglinide | Small molecule | — | Oral |
| Subject | Rivoceranib | Small molecule | — | — |
Indications
No indication recorded.